Aβ31–35-induced neuronal apoptosis is mediated by JNK-dependent extrinsic apoptosis pathway
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A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis
JNK contributes to TNF␣-mediated apoptosis remains Molecular and Cellular Biology to be addressed. Baylor College of Medicine The intrinsic apoptotic pathway is the result of activa-Houston, Texas 70030 tion of mitochondria-mediated cell death events, including changes in mitochondrial membrane permeability and subsequent release of proapoptotic factors in-Summary volved in various aspects of a...
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Trophic factor deprivation (TFD)-induced apoptosis in sympathetic neurons requires macromolecular synthesis-dependent BAX translocation, cytochrome c (cyt c) release, and caspase activation. Here, we report the contributions of other intrinsic and extrinsic pathway signals to these processes. Sympathetic neurons expressed all antiapoptotic BCL-2 proteins examined, yet expressed only certain BH3...
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Nitric oxide (NO) is recognized as a mediator and regulator of inflammatory responses. NO is produced by nitric oxide synthase (NOS), and NOS is abundantly expressed in the human dental pulp cells (HDPCs). NO produced by NOS can be cytotoxic at higher concentrations to HDPCs. However, the mechanism by which this cytotoxic pathway is activated in cells exposed to NO is not known. The purpose of ...
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Members of the tumor necrosis factor (TNF) receptor superfamily and their activating ligands transmit apoptotic signals in a variety of systems. We now show that the binding of TNF-related, apoptosis-inducing ligand (TRAIL) to its cellular receptors DR5 (TRAILR2) and DR4 (TRAILR1) mediates reovirus-induced apoptosis. Anti-TRAIL antibody and soluble TRAIL receptors block reovirus-induced apoptos...
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ژورنال
عنوان ژورنال: Neuroscience Bulletin
سال: 2009
ISSN: 1673-7067,1995-8218
DOI: 10.1007/s12264-009-0629-5